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Marmelade Gedeihen Menschlich abt 737 mechanism of action Sehr wütend Stoff Am weitesten

PROTACs are effective in addressing the platelet toxicity associated with  BCL-XL inhibitors
PROTACs are effective in addressing the platelet toxicity associated with BCL-XL inhibitors

ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of  apoptosis in multiple myeloma cells | Leukemia
ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells | Leukemia

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT- 737 in acute myeloid leukemia - ScienceDirect
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT- 737 in acute myeloid leukemia - ScienceDirect

Enhanced anticancer effect of ABT-737 in combination with naringenin on  gastric cancer cells
Enhanced anticancer effect of ABT-737 in combination with naringenin on gastric cancer cells

Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby  increasing drug resistance | EMBO reports
Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance | EMBO reports

ABT‑737, a Bcl‑2 family inhibitor, has a synergistic effect with apoptosis  by inducing urothelial carcinoma cell necroptosis
ABT‑737, a Bcl‑2 family inhibitor, has a synergistic effect with apoptosis by inducing urothelial carcinoma cell necroptosis

Attacking cancer's Achilles heel: antagonism of anti‐apoptotic BCL‐2 family  members - Opferman - 2016 - The FEBS Journal - Wiley Online Library
Attacking cancer's Achilles heel: antagonism of anti‐apoptotic BCL‐2 family members - Opferman - 2016 - The FEBS Journal - Wiley Online Library

Use of Human Cancer Cell Lines Mitochondria to Explore the Mechanisms of  BH3 Peptides and ABT-737-Induced Mitochondrial Membrane Permeabilization
Use of Human Cancer Cell Lines Mitochondria to Explore the Mechanisms of BH3 Peptides and ABT-737-Induced Mitochondrial Membrane Permeabilization

Why do BCL-2 inhibitors work and where should we use them in the clinic? |  Cell Death & Differentiation
Why do BCL-2 inhibitors work and where should we use them in the clinic? | Cell Death & Differentiation

ABT-737, a small molecule Bcl-2/Bcl-xL antagonist, increases  antimitotic-mediated apoptosis in human prostate cancer cells [PeerJ]
ABT-737, a small molecule Bcl-2/Bcl-xL antagonist, increases antimitotic-mediated apoptosis in human prostate cancer cells [PeerJ]

The Stress Protein BAG3 Stabilizes Mcl-1 Protein and Promotes Survival of  Cancer Cells and Resistance to Antagonist ABT-737* - Journal of Biological  Chemistry
The Stress Protein BAG3 Stabilizes Mcl-1 Protein and Promotes Survival of Cancer Cells and Resistance to Antagonist ABT-737* - Journal of Biological Chemistry

Targeting BCL-2 in B-cell malignancies and overcoming therapeutic  resistance | Cell Death & Disease
Targeting BCL-2 in B-cell malignancies and overcoming therapeutic resistance | Cell Death & Disease

ABT-737 overcomes Bcl-2 mediated resistance to doxorubicin–DNA adducts -  ScienceDirect
ABT-737 overcomes Bcl-2 mediated resistance to doxorubicin–DNA adducts - ScienceDirect

ABT-737 - Wikipedia
ABT-737 - Wikipedia

Synergistic co-delivery of diacid metabolite of norcantharidin and ABT-737  based on folate-modified lipid bilayer-coated mesoporous silica  nanoparticle against hepatic carcinoma | SpringerLink
Synergistic co-delivery of diacid metabolite of norcantharidin and ABT-737 based on folate-modified lipid bilayer-coated mesoporous silica nanoparticle against hepatic carcinoma | SpringerLink

Chemical structure and mode of action of the BH3 mimetic ABT-737 in... |  Download Scientific Diagram
Chemical structure and mode of action of the BH3 mimetic ABT-737 in... | Download Scientific Diagram

Discovery of Marinopyrrole A (Maritoclax) as a Selective Mcl-1 Antagonist  that Overcomes ABT-737 Resistance by Binding to and Targeting Mcl-1 for  Proteasomal Degradation* - Journal of Biological Chemistry
Discovery of Marinopyrrole A (Maritoclax) as a Selective Mcl-1 Antagonist that Overcomes ABT-737 Resistance by Binding to and Targeting Mcl-1 for Proteasomal Degradation* - Journal of Biological Chemistry

Synergistic Anticancer Effects of the 9.2.27PE Immunotoxin and ABT-737 in  Melanoma
Synergistic Anticancer Effects of the 9.2.27PE Immunotoxin and ABT-737 in Melanoma

Mechanisms of potentiation of ABT-737 lethality by strategies targeting...  | Download Scientific Diagram
Mechanisms of potentiation of ABT-737 lethality by strategies targeting... | Download Scientific Diagram

In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive  Myc-driven lymphomas | PNAS
In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas | PNAS

Bim Upregulation by Histone Deacetylase Inhibitors Mediates Interactions  with the Bcl-2 Antagonist ABT-737: Evidence for Distinct Roles for Bcl-2,  Bcl-xL, and Mcl-1 | Molecular and Cellular Biology
Bim Upregulation by Histone Deacetylase Inhibitors Mediates Interactions with the Bcl-2 Antagonist ABT-737: Evidence for Distinct Roles for Bcl-2, Bcl-xL, and Mcl-1 | Molecular and Cellular Biology

Schematic summary of the effects of ABT-737 on human oral cancer cells....  | Download Scientific Diagram
Schematic summary of the effects of ABT-737 on human oral cancer cells.... | Download Scientific Diagram

Frontiers | BH3 Mimetics for the Treatment of Prostate Cancer | Pharmacology
Frontiers | BH3 Mimetics for the Treatment of Prostate Cancer | Pharmacology

Targeting Multiple Arms of the Apoptotic Regulatory Machinery | Cancer  Research
Targeting Multiple Arms of the Apoptotic Regulatory Machinery | Cancer Research

Drugs and Clinical Approaches Targeting the Antiapoptotic Protein: A Review
Drugs and Clinical Approaches Targeting the Antiapoptotic Protein: A Review